Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Department of Medicine, University of Toronto, Toronto, ON, Canada. Hoffman-La Roche Limited, Mississauga, ON, Canada. Applied Statistician, Markham, ON, Canada. Canadian Cancer Trials Group, Queen's University, Kingston, ON, Canada. University of British Columbia, BC Cancer Agency, Vancouver, BC, Canada. McMaster University, Juravinski Cancer Centre, Hamilton, ON, Canada. Dana-Farber Cancer Institute, Boston, MA, USA. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, NY, USA. Vanderbilt University, Nashville, TN, USA. Mayo Clinic, Rochester, MN, USA. NRG Oncology and University of Pittsburgh Medical Center, Pittsburgh, PA, USA. IBCSG and Department of Oncology, Bern University Hospital, University of Bern, Bern, Switzerland. CHU de Québec-Université Laval, Québec, QC, Canada. Baylor College of Medicine, Houston, TX, USA. Cancer Research UK Clinical Trials Unit (CRCTU), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. Department of Medical Biophysics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada and University of Toronto, Toronto, ON, Canada.